Prof. Karl Friston is the most cited neuroscientist in the world, renowned for pioneering the framework of active inference and for developing the influential Free Energy Principle (FEP). In this conversation with Hans Busstra, Friston touches on the metaphysics of his FEP, which surprisingly points to non-dualism instead of materialism, as widely assumed. According to Friston, space and time, the self, and even the FEP itself are mere stories, useful fictions with real explanatory power, which do not give us direct access to the noumenal reality.

Moreira invites us into a long meditation on the meaning of digital spaces, and the possibility of finding another in the endless cacophony of simulacra. When you reach across the screen—he says—you do not know if the figure you address is real or fabricated, friend or phantom. The temptation is to strike first, to treat them as less than a person. But if there is even the chance of an Other on the far side, the only way to preserve meaning is to extend recognition before certainty. In the digital void, kindness is the only bridge that can survive simulation.

Dr. Nicolas Rouleau is a neuroscientist, bioengineer, and Assistant Professor of Health Sciences at Wilfrid Laurier University. He wrote the award-winning essay, ‘An Immortal Stream of Consciousness: The scientific evidence for the survival of consciousness after permanent bodily death,’ in which he argues that the transmissive theory of consciousness may actually be more consistent with emerging scientific insights than the dominant assumption that the brain generates consciousness. In this conversation with Hans Busstra, Rouleau shares the main arguments from his essay, which touch upon his collaboration with Dr. Michael Persinger, the inventor of the ‘God Helmet,’ and his work with Michael Levin on ‘mind blindness’—the idea that science may be searching for mind in too restricted a place by focusing almost exclusively on neurons.

Anil Seth is a world-leading neuroscientist who has made important contributions to our understanding of reality as a controlled hallucination. According to the concept of active inference, our perception of reality is not a direct reflection of the world but, instead, the most accurate guess that our brain can muster, which it continually checks and updates with incoming sensory information. But strange things happen when neuroscientists play around with sensory input in unexpected ways. Anil Seth and his team at Sussex University created the Dream Machine, a stroboscopic device that syncs flickering light to music to induce vivid, often complex, hallucinatory visuals in the viewer. In group sessions, exactly the same white light and music gives rise to a tremendous diversity in perception.

Prof. Larry Nazareth recounts the fundamental difference in perspective that underlies the Cartesian and Bergsonian views of life and world. The former’s dictum states: ‘I compute, algorithmically, therefore I think, symbolically, therefore I am, experientially.’ The latter, however, reverses this dictum: ‘I am, experientially, therefore I think, symbolically, therefore I compute, algorithmically.’ Depending on which of these views we choose to base our understanding of nature and life, we may or may not have a future, Nazareth argues.

How is it possible that the cerebellum, which contains roughly 80% of all the neurons in the human brain, can be severely damaged, or even absent, without abolishing consciousness? In this conversation, Jeremiah Hendren, a member of the Integrated Information Theory (IIT) Lab and long-term collaborator of IIT founder Giulio Tononi, joins Hans Busstra to unpack Integrated Information Theory (IIT), a theory that answers this fascinating neuroscience mystery.